2015:
150.) Möröy T, Wilkes B, Vassen L and Khandanpour C.
From cytopenias to leukemia: The role of Gfi1 and Gfi1b in blood formation.
Blood, 2015, Dec 10;126(24):2561-9.
149.) Madgwick A, Fort P, Hanson PS, Thibault P, Gaudreau MC, Lutfalla G, Möröy T, Elela SA, Chaudhry B, Elliott DJ, Morris CM and Venables JP.
Neural differentiation modulates the vertebrate brain specific splicing program.
PlosOne, 2015, May 19;10(5):e0125998.
2014:
148.) Rashkovan M, Vadnais C, Ross J, Gigoux M, Suh WK, Gu W and Möröy T.
Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.
Proc. Natl. Acad. Scie. (USA), 2014, Dec 16;111(50):E5411-9.
147.) Kosan C, Rashkovan M, Ross J, Schaffer AM, Saba I, Lemsadek W, Trudel M and Möröy T.
The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis.
American J. of Blood Research, 2014 Sep 5;4(1):7-19.
146.) Vassen L, Beauchemin H, Lemsaddek W, Krongold J, Trudel M and Möröy T.
Growth factor independence 1b (Gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression.
PlosOne, 2014, May 6;9(5):e96636.
145.) Preußner M, Wilhelmi I, Schultz AS, Finkernagel F, Michel M, Möröy T and Heyd F.
Rhythmic U2AF26 alternative splicing controls Period1 stability and the circadian clock in mice.
Molecular Cell, 2014, May 22;54(4):651-62.
2013:
144.) Phelan JD, Saba I, Olsson A, Zeng H, Kosan C, Messer MS, Fraszczak J, Hildeman D, Bruce Aronow B, Möröy T and Grimes HL.
Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.
PloS Genetics, 2013, Sep;9(9):e1003713. Epub 2013 Sep 12.
143.) Khandanpour C and Möröy T.
Gfi1 as a regulator of p53 and a therapeutic target for ALL.
Oncotarget, 2013, Mar;4(3):374-5.
142.) Khandanpour C, Phelan JD, Vassen L, Schütte J, Chen R, Horman S, Gaudreau MC, Krongold J, Zhu J, Paul WE, Dührsen U, Göttgens B, Grimes HL and Möröy T.
Growth factor independence 1 (Gfi1) antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.
Cancer Cell, 2013, Feb 11;23:200-214.
2012:
141.) Vassen L, Dührsen U, Kosan C, Zeng H and Möröy T.
Growth factor independence 1 (Gfi1) regulates cell-fate decision of a bipotential granulocytic-monocytic precursor defined by expression of Gfi1 and CD48.
Am J Blood Research, 2012;2(4):228-42.
140.) Khandanpour C, Krongold J, Schütte J, Bouwman F, Vassen L, Chen R, Gaudreau MC, Van der Reijden B, Hannah R, Diamanti E, Nieto FC, Meyer S, Grimes HL, Jansen J, Lowenberg B, Peeters JK, Patel C, Duehrsen U, Göttgens B, and Möröy T.
The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.
Blood, 2012, Nov 8;120(19):4006-17.
139.) Ligons DL, Tuncer C, Linowes BA, Akcay IM, Kurtulus S, Deniz E, Atasever Arslan B, Cevik SI, Keller HR, Luckey MA, Feigenbaum L, Möröy T, Ersahin T, Atalay R, Erman B, Park JH.
CD8 lineage specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1.
J. Biol. Chem., 2012, Oct 5;287(41):34386-99.
138.) Lancrin C, Mazan M, Stefanska M, Lichtinger M, Costa G, Wilson N, Möröy T, Goettgens B, Bonifer C, Kouskoff V and Lacaud G.
GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.
Blood, 2012, Jul 12;120(2):314-22.
137.) Gaudreau MC, Heyd F, Bastien R, Wilhelm B and Möröy T.
Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L (hnRNP L) regulates development, proliferation and migration of thymic pre-T cells.
J. Immunol., 2012, Jun 1;188(11):5377-88.
136.) Bjerknes M, Khandanpour C, Möröy T, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Martín MG, Cheng H.
Origin of the brush cell lineage in the mouse epithelium.
Dev Biol. 2012, Feb 15;362(2):194-218.
135.) Schulz D, Vassen L, Amin R, Möröy T and Schlissel M.
Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1.
J. Exp. Medicine, 2012, Jan 16;209(1):187-99
2011:
134.) Möröy T., Saba I and Kosan C.
The role of the transcription factor Miz-1 in lymphocyte development and lymphomagenesis – binding Myc makes the difference.
Seminars in Immunology, 2011, Oct;23(5):379-87.
133.) Möröy T. and Khandanpour C.
Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation.
Seminars in Immunology, 2011, Oct;23(5):368-78
132.) Saba, I, Kosan C, Vassen L, Klein-Hitpass L and Möröy T.
Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR “beta-selection” checkpoint.
Journal of Immunology, 2011, Sep 15;187(6):2982-92.
131.) Möröy T, Khandanpour C .
GFI1 (growth factor independent 1 transcription repressor).
Atlas Genet Cytogenet Oncol Haematol. 2011; 15(10):821-827. http://AtlasGeneticsOncology.org/Genes/GFI1ID40706ch1p22.html
130.) Möröy T, and Vassen L.
GFI1B (growth factor independent 1B transcription repressor).
Atlas Genet Cytogenet Oncol Haematol. 2011; 15(3):266-269. http://AtlasGeneticsOncology.org/Genes/GFI1BID40707ch9q34.html
129.) Heyd F, Chen R, Afshar K, Saba I, Lazure C, Fiolka K and Möröy T.
The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1.
BBA – Gene Regulatory Mechanisms, 2011, Apr-Jun;1809(4-6):255-61.
128.) Saba, I, Kosan C and Möröy T.
IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1.
Blood, 2011 Mar 24;117(12):3370-81.
127.) Khandanpour C, Kosan C, Gaudreau MC, Dührsen U, Zeng H and Möröy T.
Growth factor independence 1 (Gfi1) protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease.
Stem Cells, 2011 Feb 24;29:376–385.
2010:
126.) Kosan C, Saba I, Godmann M, Herold S, Herkert B, Eilers M and Möröy T.
The BTB/POZ domain protein Miz-1 (Zbtb17) is required to regulate IL-7 receptor signaling at early commitment stages of B cell differentiation.
Immunity, 2010, Dec 14;33(6):917-28.
125.) Khandanpour C, Sharif-Askari E, Gaudreau MC, Vassen L, Zhu J, Paul W, Okoyama T, Kosan C, and Möröy T.
Evidence that Growth factor independence 1b (Gfi1b) regulates dormancy and peripheral blood mobilization of hematopoietic stem cells.
Blood, 2010, Dec 9;116(24):5149-61. (Faculty 1000 Rating 6)
124.) Sharif-Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau MC, Heyd F, Okayama T, Jin J, Rojas MEB, Grimes HL, Zeng H and Möröy T.
Zinc finger protein Gfi1 controls the endotoxin-mediated TLR inflammatory response by antagonizing NF-kB p65.
Mol. Cell. Biol., 2010, Aug;30(16):3929-42.
123.) Van Riggelen J, Müller J, Otto T, Beuger V, Yetil A, Choi P, Kosan C, Möröy T, Felsher D, and Eilers M.
The interaction between Myc and Miz1 is required to antagonize TGF beta-dependent autocrine signaling during lymphoma formation and maintenance.
Genes & Development, 2010 Jun 15;24(12):1281-94.
122.) Khandanpour C,Thiede C, Valk, PJM, Sharif-Askari E, Nückel H, Lohmann D, Horsthemke B, Siffert W, Neubauer A, Grzeschik KH, Bloomfield CD, Marcucci G, Maharry K, Slovak ML, van der Reijden BA, Jansen JA, Schackert HK, Afshar K, Schnittger S, Peeters JK, Kroschinsky F, Ehninger G, Lowenberg B, Dührsen D and Möröy T.
A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.
Blood, 2010, Mar 25;115(12):2462-72.
2009:
121.) Ichiyama K, Hashimoto M, Sekiya T, Nakagawa R, Wakabayashi Y, Saba I, Möröy T, and Yoshimura A.
Gfi1 negatively regulates Th17 differentiation by inhibiting RORγt activity.
Int J. Immunol, 2009 Jul;21(7):881-9.
120.) Vassen L, Khandanpour C, Ebeling P, van der Reijden BA, Jansen JH, Mahlmann S, Dührsen U and Möröy T.
Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia.
Int. J. Hematol. 2009, May;89(4):422-30.
2008:
119.) Igwe E, Kosan C, Khandanpour C, Sharif-Askari E, Brüne B and Möröy T.
The zinc finger protein Gfi1 is implicated in the regulation of IgG production and the expression of Ig2b germ line transcripts.
Eur. J. Immunol., 2008, Nov;38(11):3004-14
118.) Kirjavainen A, Sulg M, Heyd F, Alitalo K, Ylä-Herttuala S, Möröy T, Petrova TV, Pirvola U.
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.
Dev Biol. 2008 Oct 1;322(1):33-45.
117.) Heyd F, Carmo-Fonseca, M and Möröy, T.
Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26.
J. Biol Chem., 2008, Jul 11;283(28):19636-19645.
116.) Möröy T, Zeng H, Jin J, Schmid KW, Carpinteiro A and Gulbins E.
The zinc finger protein and transcriptional repressor Gfi1 as a regulator of the innate immune response.
Immunobiology, 2008, 213(3-4):341-352
2007:
115.) Möröy T and Heyd F.
The impact of alternative splicing in vivo: mouse models show the way.
RNA, 2007, Aug;13(8):1155-71.
114.) Pargmann D, Yücel R, Kosan C, Saba I, Klein-Hitpass L, Schimmer S, Heyd F, Dittmer U and Möröy T.
Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T-lymphocyte function.
Eur. J. Immunol, 2007, 37(12):3551-63
113.) Gebhardt A, Kosan C, Herkert B, Möröy T, Lutz W, Eilers M and Elsässer HP.
Miz1 is required for hair follicle structure and hair morphogenesis.
J. Cell Science, 2007, Aug 1;120(Pt 15):2586-93.
112.) Vassen L, Okayama T and Möröy T.
Gfi1b:Green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1.
Blood, 2007, Mar 15;109(6):2356-64.
2006:
111.) Möröy T.
Interview about zinc finger protein Gfi1 and inflammation.
Modern Aspects of Immunology, 2006, 20. 6.
110.) Heyd F, ten Dam G and Möröy T.
Auxiliary splice factor U2AF26 and the transcription factor Gfi1 directly cooperate in the regulation of CD45 alternative splicing.
Nature Immunology, 2006, Aug;7(8):859-67.
109.) Vassen L, Fiolka K and Möröy T.
Gfi1b alters histone methylation at target gene promoters and sites of g-satellite containing heterochromation.
EMBO Journal, 2006, Jun 7;25(11):2409-19.
108.) Grassmé H, Jin J, Wilker B,von Kürthy G, Weller M, Möröy T* and Gulbins E*. (*co-senior authors)
Regulation of pulmonary Pseudomonas aeruginosa infections by the transcriptional repressor Gfi1.
Cellular Microbiology, 2006, Jul;8(7):1096-105.
107.) Fiolka K, Hertzano R, Vassen L, Zeng H, Hermesh O, Avraham KB Dührsen U and Möröy T.
Gfi1 and Gfi1b act equivalently in hematopoiesis but have distinct, non-overlapping functions in inner ear development.
EMBO Reports, 2006, Mar;7(3):326-33.
106.) Jin J, Zeng H, Schmid KW, Toetsch M, Uhlig S and Möröy T.
The zinc finger protein Gfi1 acts upstream of TNF to attenuate endotoxin mediated inflammatory responses in the lung.
Eur. J. Immunol., 2006, Feb;36(2):421-30.
105.) Möröy T.
Genetische Programmierung als Grundlage für die Bildung von Zellen der Immunabwehr.
Essener Unikate, 2006, 27, 8-17, ISBN 3-934359-27-2.
104.) Napirei M, Gültekin A, Kloeckl T, Möröy T, Frostegård J and Mannherz HG.Deoxyribonuclease I degrades chromatin during necrosis and prevents anti-nuclear autoimmunity.
Int. J. Biochem. Cell Biol., 2006, 38(3):297-306.
103.) Bachmann M, Kosan C, Xing P-X, Montenarh M, Hoffmann I and Möröy T.
The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.
Internat. J. Biochem. Cell Biol. 2006, 38(3):430-443.
2005:
102.) Grueter B, Petter M, Egawa T, Laule-Kilian K, Aldrian CJ, Wuerch A, Ludwig Y, Waldschütz R, Möröy T, Steimle V, Littman DR and Ehlers M.
Runx3 regulates integrin aE/CD103 and CD4 expression during development of CD4–/CD8+ T cells.
J. Immunol. 2005, Aug 1;175(3):1694-705.
101.) Rathinam C, Geffers R, Yücel R, Buer J, Welte K, Möröy T and Klein C.
The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and –function.
Immunity, 2005, Jun;22(6):717-28.
100.) Ziegler S, Rohrs S, Tickenbrock L, Möröy T, Klein-Hitpass L, Vetter IR, Müller O.
Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation.
FEBS J. 2005 Apr;272(7):1600-15.
99.) Möröy T.
Die Transkriptionsfaktoren Gfi1 und Gfi1b: Onkoproteine und Regulatoren der Hämatopoese.
FORUM (Deutsche Krebsgesellschaft) 2005
98.) Vassen L, Fiolka K, Mahlmann S and Möröy T.
Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b.
Nucleic Acids Res. 2005, Feb 17;33(3):987-98.
97.) Klein-Hitpass L and Möröy T.
Affymetrix GeneChip analyses – the impact of RNA quality.
in: DNA Microarrays (edited by U. Nuber), 2005, Taylor & Francis, London ISBN 0415358663
96.) Bachmann M and Möröy T.
Molecules in Focus: The serine/threonine kinase Pim-1 – review.
Internat. J. Biochem. Cell Biol. 2005, Apr;37(4):726-730
95.) Möröy T.
Molecules in Focus: The transcription factor “Growth factor independence 1” – Gfi1 – review.
Internat. J. Biochem. Cell Biol. 2005, Mar;37(3):541-546.
2004:
94.) Karaguni IM, Gourzoulidou E, Carpintero M, Langerak A, Klein-Hitpaß L, Möröy T, Winde G, Waldmann H, and Müller O.
SMAF-1 Inhibits the APC/-Catenin Pathway and Shows Properties Similar to Those of the Tumor Suppressor Protein APC.
ChemBioChem, 2004, 5 (9): 1267-1270.
93.) Bachmann M, Hennemann H, Xiang-Xing P, Hoffmann I and Möröy T.
The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of C-TAK1: a novel role for Pim-1 at the G2/M cell cycle checkpoint.
J. Biol. Chem., 2004, 279 (46): 48319
92.) Zeng H, Yücel R, Kosan C, Klein-Hitpass L and Möröy T.
Transcription factor Gfi1 regulates self-renewal and long-term engraftment abilities of hematopoietic stem cells by restricting their proliferative potential.
EMBO J., 2004, Oct 13;23(20):4116-25
91.) Yücel R, Kosan C, Heyd F and Möröy T.
Gfi1:Gfp knock-in mutant reveals differential expression and auto-regulation of the gene growth factor independence 1 (Gfi1) during lymphocyte development.
J. Biol. Chem., 2004, Sep 24;279(39):40906-17.
90.) Hertzano R, Montcouquiol M,Rashi-Elkeles S, Elkon R, Yücel R, Frankel WF, Rechavi G, Möröy T, Friedman TB, Kelley MW and Avraham KW.
Transcription profiling of inner ears from Pou4f3ddl/ddl identifies Gfi1 as a target of the Pou4f3 deafness gene.
Hum. Mol. Genet., 2004, Sep 15;13(18):2143-53
89.) Möröy T and Geisen C.
Cyclin E – review.
Internat. J. Biochem. Cell Biol. 2004, Aug;36(8):1424-39.
88.) Rother K, Johne C, Spiesbach K, Haugwitz U, Tschöp K, Wasner M, Klein-Hitpass L, Möröy T, Mössner J and Engeland K.
Identification of Tcf-4 as a transcriptional target of p53 signalling.
Oncogene, 2004, Apr 22;23(19):3376-84.
87.) Müller O, Gourzoulidou, Carpintero M, Karaguni I-M, Langerak A., Herrmann C, Möröy T, Klein-Hitpass L and Waldmann H.
Identification of potent Ras signaling inhibitors by pathway-selective phenotyp-based screening.
Angew. Chemie, 2004, 116: 456-460.
86.) Möröy T, Klein-Hitpass L.
Zukunft Biochips. Mikroarrays – Zukunftstechnologie für genetische Grundlagenfoschung.
Forum Forschung, Universität Duisburg-Essen, Essen, Germany, 2003-2004, 70-73.
2003:
85.) Dürig J, Nückel H, Cremer M, Führer A, Halfmeyer K, Fandrey J, Möröy T, Klein-Hitpass L, Dührsen U.
ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia.
Leukemia. 2003 Dec;17(12):2426-34.
84.) Kaiser FJ, Möröy T, Chang GTG, Horsthemke B and Lüdecke HJ.
The RING finger protein RNF4, a coregulator of transcription, interacts with the TRPS1 transcription factor.
J. Biol. Chem., 2003 Oct 3;278(40):38780-5.
83.) Adhikary A, Peukert K, Karsunky H, Elsässer HP, Lutz W, Möröy T and Eilers M.
Miz1 is required for early embryonic development during gastrulation.
Mol. Cell. Biol., 2003, 23: 7648-7657.
82.) Hennemann H, Vassen L., Geisen G, Eilers M and Möröy T.
Identification of a novel KRAB box domain protein – KRIM-1 – that interacts with c-Myc and inhibits its oncogenic activity.
J. Biol. Chem., 2003, Aug 1;278(31):28799-811.
81.) Kaiser FJ, Tavassoli K, Van den Bemd GJ, Chang G, Horsthemke B, Möröy T and Lüdecke HJ.
Nuclear interaction of the dynein light chain LC8a with the TRPS1 transcription factor suppresses the transcriptional repression activity of TRPS1.
Hum. Mol. Genet, 2003, Jun 1;12(11):1349-58.
80.) Mädge B, Geisen C, Möröy T and Schwab M.
Yaf2 inhibits Myc biological function.
Cancer Letters, 2003 Apr 25;193(2):171-6.
79.) Yücel R, Karsunky H, Klein-Hitpass L and Möröy T.
The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T-cell progenitors and CD4/CD8 lineage decision in the thymus.
J. Exp. Med., 2003 Apr 7;197(7):831-44.
78.) Dürig J, Nückel H, Hüttmann A, Hölter T, Kruse E, Halfmeyer K, Führer A, Rudolph R, Kalhori N, Nusch A, Deaglio S, Malavasi F, Möröy T, Klein-Hitpass L and Dührsen U.
Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia.
Blood. 2003, Apr 1;101(7):2748-2755.
77.) Geisen C, Karsunky H, Yücel R and Möröy T.
Loss of p27Kip1 cooperates with cyclin E in T cell lymphomagenesis.
Oncogene, 2003, Mar 20;22(11):1724-9.
2002:
76.) Geisen C, Möröy T.
The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein.
J. Biol. Chem. 2002 Oct 18, 277 (42): 39909-39918.
75.) Frass B, Vassen L and Möröy T.
Gene expression of the POU factor Brn-3a is regulated by two different promoters.
Biochim. Biophys. Acta, 2002 Dec 12;1579(2-3):207-13.
74.) Herborn CU, Waldschütz R, Lauenstein TC, Goyen M, Lauffer RB, Möröy T, Debatin JF, Ruehm SG.
Contrast-enhanced magnetic resonance imaging (MS-325) in a murine model of systemic lupus erythematosus.
Invest Radiol. 2002 Aug;37(8):464-9.
73.) Karaguni I, Herter P, Debruyne P, Chtarbova S, Kasprzynski A, Herbrand U, Ahmadian M, Glüsenkamp K, Winde G, Mareel M, Möröy T, Müller O.
The new Sulindac derivative IND 12 reverses Ras induced cell transformation.
Cancer Res, 2002 62: 1718-1723.
72.) Karsunky H, Mende I, Schmidt T and Möröy T.
High levels of the Onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells.
Oncogene. 2002, 21: 1571-1579
71.) Karsunky H, Zeng H, Schmidt T, Zevnik B, Kluge R, Schmid KW, Dührsen U and Möröy T.
Inflammatory Reactions and Severe Neutropenia in Mice Lacking the Transcriptional Repressor Gfi-1.
Nature Genetics. 2002, Vol 30 No.3, 295-300
70.) Karaguni IM, Glüsenkamp KH, Langerak A, Geisen C, Ullrich V,Winde G, Möröy T and Müller O.
New indene-derivatives with anti-proliferative properties.
Bioorg. & Medic. Chem. Lett. 2002, 12: 709-713
69.) Möröy T.
DNA microarrays in medicine – can the promises be kept?
J Biomed Biotech, 2:1 (2002), 1-2
2001:
68.) Beneke R and Möröy T.
Inhibition of poly(ADP-ribose)polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice.
Oncogene. 2001 Dec 6; 20(56): 8136-8141.
67.) Staller P, Peukert K, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massague J, Hänel F, Eilers M.
Repression of p15ink4b expression by Myc via association with Miz-1.
Nature Cell Biology. 2001, Apr;3(4):392-399.
66.) Klein-Hitpaß L und Möröy T.
DNA-Mikroarrays: eine neue Technologie zur Erstellung von RNA-Expressionsprofilen auf Genomebene.
Biospektrum (2001) 2, 150-156
65.) Klein-Hitpaß L und Möröy T.
Der Biochip, ein neuer Horizont in Prävention, Diagnose und Nachsorge von Tumorerkrankunge.
Essener Unikate (2001) 15, 12-19
64.) Möröy T., Zörnig M, Schmidt T.
Retroviral tagging with MoMuLV and the discovery of new oncogenes.
Perspectives in Medical Virology, Viruses, Cell Transformation and Cancer (R.J.A. Grand ed.) (2001), 321-349
2000:
63.) Rödel B, Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, Heinrich P, Shuai K, Elsässer HP, Möröy T.
The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.
EMBO J. 2000;19: 5845-5855
62.) Leduc I, Karsunky H., Mathieu N, Schmidt T, Verthuy C, Ferrier P, Möröy T.
The Pim-1 kinase stimulates maturation of TCRß deficient T-cell progenitors: implications for the mechanism of Pim-1 action.
Int. Immunol. 2000 Oct;12(10):1389-1396
61.) Beier R, Bürgin A, Kiermeier A, Fero M, Karsunky H, Saffrich R, Möröy T, Ansorge W, Roberts J, Eilers M.
Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events.
EMBO J. 2000;19: 5813-5823.
60.) Schmidt T, Karsunky H, Frass B, Baum W, Denzel A, Möröy T.
A novel protein – Fbf-1 – that binds to CD95/Apo-1/Fas and shows sequence similarity to trichohyalin and Plectin.
Bioch. Biophys. Acta. 2000 Sep 7;1493(1-2):249-254.
59.) Beneke R, Geisen C, Zevnik B, Küpper JH, Möröy T.
DNA excision repair and DNA damage-induced apoptosis are linked to poly(ADP-ribosyl)ation but have different requirements for p53.
Mol. Cell. Biol. 2000 Sep. 20 (18): 6695-6703
58.) Napirei M, Karsunky H, Zevnik B, Stephan H, Mannherz HG, Möröy T.
Features of systemic lupus erythematosus in Dnase1-deficient mice.
Nature Genetics. 2000 Jun;25(2):177-81.
57.) Möröy T, Karsunky H.
Regulation of pre T-cell development.
Cell. Mol. Life Sci., (2000) 57, 957-975
1999:
56.) Karsunky H, Geisen C, Schmidt T, Haas K, Zevnik B, Gau E, Möröy T.
Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc.
Oncogene. 1999 Dec 16;18(54):7816-24.
55.) Plaza S, Hennemann H, Möröy T, Saule S, Dozier C.
Evidence that POU factor Brn-3B regulates expression of Pax-6 in neuroretina cells.
J Neurobiol. 1999 Nov 15;41(3):349-58.
54.) Schmidt T, Körner K, Karsunky H, Korsmeyer S, Muller R, Möröy T.
The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53.
Cell Death Differ. 1999 Sep;6(9):873-82.
53.) Rimpler MM, Rauen U, Schmidt T, Möröy T, de Groot H.
Protection against hydrogen peroxide cytotoxicity in rat-1 fibroblasts provided by the oncoprotein Bcl-2: maintenance of calcium homoeostasis is secondary to the effect of Bcl-2 on cellular glutathione.
Biochem J. 1999 May 15;340 ( Pt 1):291-7.
1998:
52.) Rödel B, Wagner T, Zörnig M, Niessing J, Möröy T.
The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases.
Genomics. 1998 Dec 15;54(3):580-2.
51.) Schmidt T, Karsunky H, Gau E, Zevnik B, Elsasser HP, Möröy T.
Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis.
Oncogene. 1998 Nov 19;17(20):2661-7.
50.) Braun K, Hölzl G, Soucek T, Geisen C, Möröy T, Hengstschlager M.
Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation.
Oncogene. 1998 Oct 29;17(17):2259-69.
49.) Herrmann C, Block C, Geisen C, Haas K, Weber C, Winde G, Möröy T, Muller O.
Sulindac sulfide inhibits Ras signaling.
Oncogene. 1998 Oct 8;17(14):1769-76.
48.) Schmidt T, Karsunky H, Rödel B, Zevnik B, Elsässer HP, Möröy T.
Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection.
EMBO J. 1998 Sep 15;17(18):5349-59.
47.) Möröy T.
Restriction point control in human cancer.
Tumordiagn & Therap, (1998) 19, 93-100.
1997:
46.) Haas K, Johannes C, Geisen C, Schmidt T, Karsunky H, Blass-Kampmann S, Obe G, Möröy T.
Malignant transformation by cyclin E and Ha-Ras correlates with lower sensitivity towards induction of cell death but requires functional Myc and CDK4.
Oncogene. 1997 Nov 20;15(21):2615-23.
45.) Haas K, Staller P, Geisen C, Bartek J, Eilers M, Möröy T.
Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16INK4A as upstream regulators of Myc.
Oncogene. 1997 Jul 10;15(2):179-92.
1996:
44.) Mumberg D, Haas K, Möröy T, Niedenthal R, Hegemann JH, Funk M, Muller R.
Uncoupling of DNA replication and cell cycle progression by human cyclin E.
Oncogene. 1996 Dec 5;13(11):2493-7.
43.) Schmidt T, Zörnig M, Beneke R, Möröy T.
MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene.
Nucleic Acids Res. 1996 Jul 1;24(13):2528-34.
42.) Zörnig M, Schmidt T, Karsunky H, Grzeschiczek A, Möröy T.
Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2.
Oncogene. 1996 Apr 18;12(8):1789-801.
41.) Dawson SJ, Liu YZ, Rödel B, Möröy T, Latchman DS.
The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements.
Biochem J. 1996 Mar 1;314 ( Pt 2):439-43.
40.) Möröy T, Zörnig M.
Regulators of life and death: the bcl-2 gene family.
J. Cell. Physiol. and Bioch., (1996) 6, 6, 1-24
1995:
39.) Theil T, Rödel B, Spiegelhalter F, Möröy T.
Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding.
J Biol Chem. 1995 Dec 29;270(52):30958-64.
38.) Zörnig M, Busch G, Beneke R, Gulbins E, Lang F, Ma A, Korsmeyer S, Möröy T.
Survival and death of prelymphomatous B-cells from N-myc/bcl-2 double transgenic mice correlates with the regulation of intracellular Ca2+ fluxes.
Oncogene. 1995 Nov 16;11(10):2165-74.
37.) Lakin ND, Morris PJ, Theil T, Sato TN, Möröy T, Wilson MC, Latchman DS.
Regulation of neurite outgrowth and SNAP-25 gene expression by the Brn-3a transcription factor.
J Biol Chem. 1995 Jun 30;270(26):15858-63.
36.) Zörnig M, Grzeschiczek A, Kowalski MB, Hartmann KU, Möröy T.
Loss of Fas/Apo-1 receptor accelerates lymphomagenesis in E mu L-MYC transgenic mice but not in animals infected with MoMuLV.
Oncogene. 1995 Jun 15;10(12):2397-401
35.) Lillycrop KA, Liu YZ, Theil T, Möröy T, Latchman DS.
Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors.
Biochem J. 1995 Apr 15;307 ( Pt 2):581-4.
34.) Budhram-Mahadeo V, Morris PJ, Lakin ND, Theil T, Ching GY, Lillycrop KA, Möröy T, Liem RK, Latchman DS.
Activation of the alpha-internexin promoter by the Brn-3a transcription factor is dependent on the N-terminal region of the protein.
J Biol Chem. 1995 Feb 10;270(6):2853-8.
33.) Zörnig M, Klett C, Lovec H, Hameister H, Winking H, Adolph S, Möröy T.
Establishment of permanent wild-mouse cell lines with readily identifiable marker chromosomes.
Cytogenet Cell Genet. 1995;71(1):37-40.
32.) Sedlacek HH, Möröy T.
Immune reactions: Headlines, overviews, tables and graphics.
Springer Verlag, (1995), Heidelberg
1994:
31.) MacLean-Hunter S, Makela TP, Grzeschiczek A, Alitalo K, Möröy T.
Expression of a rlf/L-myc minigene inhibits differentiation of embryonic stem cells and embroid body formation.
Oncogene. 1994 Dec;9(12):3509-17.
30.) Morris PJ, Theil T, Ring CJ, Lillycrop KA, Möröy T, Latchman DS.
The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain.
Mol Cell Biol. 1994 Oct;14(10):6907-14.
29.) Budhram-Mahadeo V, Theil T, Morris PJ, Lillycrop KA, Möröy T, Latchman DS.
The DNA target site for the Brn-3 POU family transcription factors can confer responsiveness to cyclic AMP and removal of serum in neuronal cells.
Nucleic Acids Res. 1994 Aug 11;22(15):3092-8.
28.) Lovec H, Grzeschiczek A, Kowalski MB, Möröy T.
Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.
EMBO J. 1994 Aug 1;13(15):3487-95.
27.) Oswald F, Lovec H, Möröy T, Lipp M.
E2F-dependent regulation of human MYC: trans-activation by cyclins D1 and A overrides tumour suppressor protein functions.
Oncogene. 1994 Jul;9(7):2029-36.
26.) Lovec H, Sewing A, Lucibello FC, Muller R, Möröy T.
Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation.
Oncogene. 1994 Jan;9(1):323-6.
25.) Theil T, Zechner U, Klett C, Adolph S, Möröy T.
Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes.
Cytogenet Cell Genet. 1994;66(4):267-71.
24.) Bierbaum P, MacLean-Hunter S, Ehlert F, Möröy T, Muller R.
Cloning of embryonal stem cell-specific genes: characterization of the transcriptionally controlled gene esg-1.
Cell Growth Differ. 1994 Jan;5(1):37-46.
1993:
23.) Theil T, McLean-Hunter S, Zörnig M, Möröy T.
Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a.
Nucleic Acids Res. 1993 Dec 25;21(25):5921-9.
22.) Möröy T, Grzeschiczek A, Petzold S, Hartmann KU.
Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice.
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10734-8.
21.) Ma A, Möröy T, Collum R, Weintraub H, Alt FW, Blackwell TK.
DNA binding by N- and L-Myc proteins.
Oncogene. 1993 Apr;8(4):1093-8.
1992:
20.) Collum RG, Fisher PE, Datta M, Mellis S, Thiele C, Huebner K, Croce CM, Israel MA, Theil T, Möröy T, et al.
A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.
Nucleic Acids Res. 1992 Sep 25;20(18):4919-25.
19.) Möröy T, Fisher PE, Lee G, Achacoso P, Wiener F, Alt FW.
High frequency of myelomonocytic tumors in aging E mu L-myc transgenic mice.
J Exp Med. 1992 Feb 1;175(2):313-22.
1991:
18.) Möröy T, Verbeek S, Ma A, Achacoso P, Berns A, Alt F.
E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice.
Oncogene. 1991 Nov;6(11):1941-8.
17.) Möröy T, Alt FW, DePinho R.
Use of transgenic mice to study normal and abnormal mammalian development.
Molecular Foundations of Oncology, (1991, S. Broder, ed) 455-487.
1990:
16.) Möröy T, Fisher P, Guidos C, Ma A, Zimmerman K, Tesfaye A, DePinho R, Weissman I, Alt FW.
IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis.
EMBO J. 1990 Nov;9(11):3659-66.
15.) Ma A, Möröy T, Charron J, Dildrop R, Yancopoulos G, Tesfaye A, Zimmerman K, Rosenberg N, Goff S, Alt FW.
Function of differential myc family gene expression. Transgenic and homologous recombination models.
Growth Regulation of Cancer -II, (1990, Alan R.Liss, New York), 115, 17-31
14.) Etiemble J, Möröy T, Buendia MA.
Cours pratique du génie génétique: Préparation et charactérisation des ARNm, synthèse de cDNA, clonage et séquençage.
Colloque Inserm, (1990), Les Editions INSERM, Paris
1989:
13.) Etiemble J, Möröy T, Jacquemin E, Tiollais P, Buendia MA.
Fused transcripts of c-myc and a new cellular locus, hcr in a primary liver tumor.
Oncogene. 1989 Jan;4(1):51-7.
12.) Möröy T, Etiemble J, Bougueleret L, Hadchouel M, Tiollais P, Buendia MA.
Structure and expression of hcr, a locus rearranged with c-myc in a woodchuck hepatocellular carcinoma.
Oncogene. 1989 Jan;4(1):59-65.
1988:
11.) Hsu T, Möröy T, Etiemble J, Louise A, Trepo C, Tiollais P, Buendia MA.
Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma.
Cell. 1988 Nov 18;55(4):627-633.
10.) Etiemble J, Möröy T, Trépo C, Tiollais P, Buendia MA.
Transcription of WHV in chronically infected liver and in hepatocellular carcinoma.
Viral Hepatitis and Liver Disease (1988, A.J. Zuckerman ed.), Alan R. Liss, New York, 484-487.
9.) Pourcel C, Hadchouel M, Salmon AM, Möröy T, Tiollais P, Babinet C, Farza H.
The use of transgenic mice containing Hepatitis B Virus DNA as a model for HBV Infection.
Viral Hepatitis and Liver Disease, 1(1988, A.J. Zuckerman ed.), Alan R. Liss, New York, 381-385.
8.) Möröy T, Marchio A, Etiemble J, de Thé H, Buendia MA, Tiollais P, Dejean A.
Two different Mechanisms for Hepatitis B Virus induced hepatocellular carcinoma.
Viral Hepatitis and Liver Disease (1988, A.J. Zuckerman ed.), Alan R. Liss, New York, 737-745.
1987:
7.) Möröy T, Hadchouel M, Tiollais P, Buendia MA.
More clues to gene rearrangement.
Nature, (1987), 325, 396
1986:
6.) Möröy T, Marchio A, Etiemble J, Trepo C, Tiollais P, Buendia MA.
Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks.
Nature. 1986 Nov 20-26;324(6094):276-9.
5.) Seckler R, Möröy T, Wright JK, Overath P.
Anti-peptide antibodies and proteases as structural probes for the lactose/H+ transporter of Escherichia coli: a loop around amino acid residue 130 faces the cytoplasmic side of the membrane.
Biochemistry. 1986 May 6;25(9):2403-9.
4.) Etiemble J, Möröy T, Trepo C, Tiollais P, Buendia MA.
Nucleotide sequence of the woodchuck hepatitis virus surface antigen mRNAs and the variability of three overlapping viral genes.
Gene. 1986;50(1-3):207-14.
1985:
3.) Möröy T, Etiemble J, Trepo C, Tiollais P, Buendia MA.
Transcription of woodchuck hepatitis virus in the chronically infected liver.
EMBO J. 1985 Jun;4(6):1507-14.
2.) Wright JK, Dornmair K, Mitaku S, Möröy T, Neuhaus JM, Seckler R, Vogel H, Weigel U, Jähnig F, Overath P.
Lactose:H+ carrier of E. coli: kinetic, mechanism and structure.
Ann. N.Y. Acad. of Sci., (1985), 456, 326-34
1984:
1.) Schaefer-Ridder M, Möröy T, Engelhardt U.
Inactivation of the thymidine kinase gene after in vitro modification with benzo(a)pyrene-diol-epoxide and transfer to LTK- cells as a eukaryotic test for carcinogens.
Cancer Res. 1984 Dec;44(12 Pt 1):5861-5866.